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KMID : 0383820070620050432
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Tuberculosis and Respiratory Diseases
2007 Volume.62 No. 5 p.432 ~ p.436
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Dramatic Tumor Response to 2nd-line Pemetrexed/Cisplatin Combination Chemotherapy in Patient with Malignant Pleural Mesothelioma
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Lee Seung-Min
Seo Tae-Ho
Lee Jung-Hyun
Choi Seungo-O
Lee Jeong-Geun
Kim Wan-Seop
Ko Soon-Young
Lee Tae-Hoon
Yoo Kwang-Ha
Lee Kye-Young
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Abstract
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Malignant pleural mesothelioma (MPM) is a rare tumor that is difficult to clearly distinguish from an adenocarcinoma but usually has a poor prognosis. Numerous cytotoxic agents have been used in the primary treatment of MPM with limited success. A complete response is unusual and a partial response occurs in less than one-third of patients. Recently, a phase III trial showed that a combination of pemetrexed with cisplatin resulted in a significantly higher response rate and median survival time than with cisplatin alone. We encountered a case of a dramatic tumor response to pemetrexed/cisplatin combination chemotherapy in patients with MPM, which was resistant to the 1st-line gemcitabine/cisplatin therapy. After six cycles of pemetrexed/cisplatin combination chemotherapy, the tumor volume had decreased dramatically with complete symptom relief. There was no chemotherapy-related toxicity or scheduled violation. The patient is under maintenance chemotherapy with the same regimen.
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KEYWORD
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Malignant pleural mesothelioma, Pemetrexed, Cisplatin
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